Polygonum multiflorum-Induced Liver Injury: Clinical Characteristics, Risk Factors, Material Basis, Action Mechanism and Current Challenges
Wang Y, Wang L, Saxena R, Wee A, Yang R, Tian Q, Zhang J, Zhao X, Jia J
Published in Frontiers in Pharmacology
Methodology
Review synthesising clinical characteristics, susceptibility factors and candidate hepatotoxins of Polygonum multiflorum liver injury.
Key Findings
Injury is typically idiosyncratic and immune-mediated, associated with the HLA-B*35:01 allele; cis-stilbene glucoside and anthraquinones are the leading candidate toxins.
Conclusions
Fo-Ti hepatotoxicity is idiosyncratic and host-dependent, not simply dose-dependent.
Limitations
Narrative synthesis; genetic association data from limited Chinese cohorts.
Supplements Studied
Polygonum multiflorum liver injury is largely idiosyncratic and immune-mediated, with a strong association to the HLA-B*35:01 allele.
Study Details
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