Systematic review and meta-analysis of the effects of iodine supplementation on thyroid function and child neurodevelopment in mildly-to-moderately iodine-deficient pregnant women
Dineva M, Fishpool H, Rayman MP, Mendis J, Bath SC
Published in American Journal of Clinical Nutrition
Methodology
Systematic review and meta-analysis of randomised and observational studies of iodine supplementation in mildly to moderately deficient pregnancy
Key Findings
Supplementation improved maternal iodine status and reduced thyroglobulin, but had no consistent effect on maternal thyroid hormones or child neurodevelopmental scores.
Conclusions
Iodine repletion in mild deficiency corrects biomarkers without demonstrated cognitive benefit.
Limitations
Mixed study designs; heterogeneity in timing and dose.
Supplements Studied
Supplementation improved maternal iodine status and reduced thyroglobulin, but had no consistent effect on maternal thyroid hormones or child neurodevelopmental scores.
Outcomes Measured
Supplementation improved maternal iodine status and reduced thyroglobulin, but had no consistent effect on maternal thyroid hormones or child neurodevelopmental scores.
Study Details
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