Symptomatic efficacy of avocado-soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials
Christensen R, et al
Published in Osteoarthritis and Cartilage
Methodology
Systematic review and meta-analysis of randomised placebo-controlled trials of avocado-soybean unsaponifiables in hip or knee osteoarthritis, pooling standardised mean differences for pain and function.
Key Findings
Meta-analysis of four randomised trials (664 patients) found avocado-soybean unsaponifiables reduced pain and improved function in hip and knee osteoarthritis versus placebo, with benefit clearer in knee than hip OA and one long trial showing no structural joint-space benefit.
Conclusions
ASU provides a modest symptomatic benefit in osteoarthritis, particularly of the knee, without demonstrated structure-modifying effect.
Limitations
Only four trials with heterogeneity between hip and knee populations, most funded by the product manufacturer, varying outcome instruments, and no evidence of joint structure preservation.
Related Health Concerns
Study Details
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Disclosures
Funding
Partially industry-supported (ASU manufacturer)
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