Effect of oral gamma-aminobutyric acid (GABA) administration on stress and sleep in humans: a systematic review
Hepsomali P, Groeger JA, Nishihira J, Scholey A
Published in Frontiers in Neuroscience
Key Findings
Across 14 studies, oral GABA produced modest reductions in acute stress markers and shortened sleep latency in a minority of trials; central penetration remained unestablished.
Conclusions
Limited but consistent evidence for acute stress reduction; sleep evidence is weaker and requires larger trials.
Limitations
Small samples, heterogeneous doses, frequent industry funding and reliance on EEG proxies.
Supplements Studied
Across 14 studies, oral GABA produced modest reductions in acute stress markers, with central penetration unestablished.
Outcomes Measured
Across 14 studies, oral GABA produced modest reductions in acute stress markers, with central penetration unestablished.
Study Details
Access Study
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.