Intranasal corticosteroids versus oral H1 receptor antagonists in allergic rhinitis: systematic review of randomised controlled trials
Weiner JM, Abramson MJ, Puy RM
Published in BMJ
Abstract
Systematic review of 16 randomised controlled trials comparing intranasal corticosteroids with oral H1 antihistamines for the treatment of allergic rhinitis.
Methodology
Meta-analysis of 16 RCTs comparing intranasal corticosteroids to oral H1 antihistamines, using standardized mean differences for symptom scores.
Key Findings
Intranasal corticosteroids were significantly more effective than oral antihistamines in relieving nasal symptoms of allergic rhinitis, including sneezing, congestion, itching, and rhinorrhoea.
Conclusions
Intranasal corticosteroids should be considered first-line therapy for allergic rhinitis in patients whose predominant symptoms are nasal.
Limitations
Included trials varied in quality, dosing, and duration; publication bias not fully assessable; older antihistamine formulations used.
Related Health Concerns
Study Details
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