meta_analysis
    2021
    High Quality

    Comparative effectiveness of probiotic strains for the treatment of pediatric atopic dermatitis: A systematic review and network meta-analysis

    Tan-Lim CSC, Esteban-Ipac NAR, Mantaring JBV, Chan Shih Yen E, Recto MST

    Published in Pediatric Allergy and Immunology

    Methodology

    Systematic review and network meta-analysis of 22 randomised controlled trials covering 28 probiotic strains for paediatric atopic dermatitis, searched to January 2020 and appraised with GRADE.

    Key Findings

    A mixture containing B. bifidum with L. acidophilus, L. casei and L. salivarius (Mix6) probably reduced atopic dermatitis symptoms versus placebo (SMD -0.85, 95% CI -1.50 to -0.20), based on moderate certainty evidence from only 40 participants.

    Conclusions

    Certain probiotic mixtures including B. bifidum may reduce paediatric atopic dermatitis severity, but strain-level evidence is sparse and imprecise.

    Limitations

    Very small contributing trials; indirect network comparisons; B. bifidum only tested as part of multi-strain mixtures, so single-strain effects are unknown.

    Supplements Studied

    Mix6 compared with placebo probably reduces atopic dermatitis symptoms based on moderate certainty evidence (SMD -0.85, 95% CI -1.50 to -0.20; 40 participants).

    Related Health Concerns

    Study Details

    Year:2021
    Quality Score:7/10

    Disclosures

    Funding

    No commercial funding reported

    This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.