A Comprehensive Review on Chrysin: Emphasis on Molecular Targets, Pharmacological Actions and Bio-pharmaceutical Aspects
Garg A, Chaturvedi S
Published in Current Drug Targets
Methodology
Comprehensive review of chrysin molecular targets, pharmacology and biopharmaceutics
Key Findings
Anticancer, antidiabetic, immunomodulatory, antidepressant and organ-protective actions are reported, but extensive first-pass metabolism limits therapeutic application.
Conclusions
Delivery technology, not additional target discovery, is the bottleneck for chrysin.
Limitations
Preclinical evidence only; no quantitative pooling.
Supplements Studied
However, its therapeutic applications have been limited due to its poor oral bioavailability. The major reason for its poor bioavailability is its extensive first-pass metabolism.
Study Details
Access Study
Disclosures
Funding
Not reported
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