rct
    2001
    High Quality

    Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomised, placebo controlled study

    Schellenberg R

    Published in BMJ

    Methodology

    Three-cycle randomised, double-blind, placebo-controlled trial of Vitex agnus castus extract Ze 440 in 178 women with premenstrual syndrome.

    Key Findings

    Responder rate was 52% with agnus castus versus 24% with placebo, with improvements in irritability, mood, anger, headache and breast fullness.

    Conclusions

    Agnus castus fruit extract is an effective and well tolerated treatment for premenstrual syndrome.

    Limitations

    Single manufacturer-sponsored extract; three-cycle duration; self-reported symptom scales.

    Supplements Studied

    Responder rate was 52% with agnus castus versus 24% with placebo in women with premenstrual syndrome.

    Related Health Concerns

    Premenstrual Bloating
    Premenstrual Syndrome (PMS)

    Study Details

    Year:2001
    Sample Size:178
    Duration:12 weeks
    Quality Score:8/10

    Access Study

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