Hydrastis canadensis (goldenseal) extracts and antibacterial synergy: mechanistic and safety review
Mandal SM, Chakraborty D, Dey S
Published in Journal of Ethnopharmacology
Methodology
Review of in vitro antimicrobial and efflux-pump-inhibition data for goldenseal alkaloids alongside available human safety data
Key Findings
Goldenseal alkaloids show in vitro antibacterial and efflux-pump inhibitory activity, but no controlled human trials support use for infections.
Conclusions
Traditional antimicrobial use of goldenseal remains unsupported by clinical trial evidence.
Limitations
Predominantly in vitro data; no human efficacy trials.
Supplements Studied
Goldenseal alkaloids show in vitro antibacterial and efflux pump inhibitory activity, but no controlled human trials support use for infections.
Outcomes Measured
Goldenseal alkaloids show in vitro antibacterial and efflux-pump inhibitory activity, but no controlled human trials support use for infections.
Study Details
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