Clinical relevance of St. John's wort drug interactions revisited
Nicolussi S, Drewe J, Butterweck V, Meyer Zu Schwabedissen HE
Published in British Journal of Pharmacology
Methodology
Review of pharmacokinetic interaction data for Hypericum preparations, stratified by hyperforin content.
Key Findings
High-hyperforin extracts induce CYP3A4 and P-glycoprotein and can reduce levels of contraceptives, anticoagulants, immunosuppressants and antiretrovirals; low-hyperforin products show minimal induction.
Conclusions
Interaction risk with St John's wort depends strongly on hyperforin dose in the preparation used.
Limitations
Narrative synthesis; heterogeneous interaction study designs.
Supplements Studied
Interaction risk with St John's wort depends strongly on hyperforin dose in the preparation used.
Related Health Concerns
Study Details
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