Betaine HCl restores gastric acidity during pharmacologically induced hypochlorhydria in healthy volunteers
Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ
Published in Molecular Pharmaceutics
Methodology
Open-label crossover pharmacodynamic study measuring intragastric pH after betaine hydrochloride in healthy volunteers made hypochlorhydric with rabeprazole.
Key Findings
Betaine HCl rapidly re-acidified the stomach, dropping gastric pH from above 5 to below 3 within minutes and restoring dissolution conditions for weak-base drugs.
Conclusions
Betaine HCl temporarily restores gastric acid in low-acid states.
Limitations
Very small sample; induced rather than natural hypochlorhydria.
Supplements Studied
Betaine HCl rapidly re-acidified the stomach, dropping gastric pH from above 5 to below 3 within minutes
Outcomes Measured
Betaine HCl rapidly re-acidified the stomach, restoring dissolution conditions for weak-base drugs
Study Details
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