Vitamin A supplementation every 6 months with retinol in 1 million pre-school children in north India: DEVTA, a cluster-randomised trial
Awasthi S, Peto R, Read S, Clark S, Pande V, Bundy D
Published in The Lancet
Methodology
Cluster-randomised trial of six-monthly retinol versus control in about one million pre-school children in Uttar Pradesh, India.
Key Findings
Mortality was 4% lower in the supplemented clusters, a non-significant difference far smaller than earlier trials suggested.
Conclusions
Routine six-monthly vitamin A did not produce the large mortality reduction seen in older studies in this population.
Limitations
Cluster design with limited individual outcome ascertainment; contested mortality capture methods.
Supplements Studied
Mortality was 4% lower in supplemented clusters, a non-significant difference far smaller than earlier trials suggested.
Study Details
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