rct
2006
High Quality
The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride
Unknown authors
Published in Journal of the American Academy of Dermatology
Key Findings
Dual type 1 and 2 inhibition with dutasteride reduced scalp and serum DHT more than finasteride and increased hair count dose-dependently.
Conclusions
Degree of DHT suppression tracks with clinical benefit, supporting 5AR inhibition as the mechanism.
Limitations
24-week duration; high doses not used clinically.
Outcomes Measured
Dutasteride increased target area hair count versus placebo in a dose-dependent fashion and dutasteride 2.5 mg was superior to finasteride at 12 and 24 weeks.
Study Details
Year:2006
Sample Size:416
Duration:24 weeks
Quality Score:8/10
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