Effect of goldenseal (Hydrastis canadensis) and kava kava (Piper methysticum) supplementation on digoxin pharmacokinetics in humans
Gurley BJ, Swain A, Barone GW, Williams DK, Breen P, Yates CR
Published in Drug Metabolism and Disposition
Methodology
Open-label crossover study of digoxin pharmacokinetics in healthy volunteers before and after 14 days of goldenseal or kava supplementation
Key Findings
Neither goldenseal nor kava significantly altered digoxin pharmacokinetics, indicating no meaningful P-glycoprotein-mediated interaction.
Conclusions
Goldenseal does not appear to affect P-glycoprotein substrate disposition, in contrast with its CYP effects.
Limitations
Single P-gp probe; small sample of healthy adults.
Supplements Studied
Neither goldenseal nor kava kava significantly altered digoxin pharmacokinetics.
Neither goldenseal nor kava significantly altered digoxin pharmacokinetics, indicating no meaningful P-glycoprotein-mediated interaction.
Study Details
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