Effects of indole-3-carbinol on estrogen metabolism and breast density: null findings from a randomised biomarker trial
Maskarinec G, Morimoto Y, Novotny R, Nordt FJ, Stanczyk FZ, Franke AA
Published in European Journal of Clinical Nutrition
Methodology
Randomised crossover feeding trial of cruciferous indole supplementation examining urinary estrogen metabolites and mammographic density in women
Key Findings
Estrogen metabolite ratios shifted modestly but mammographic density and circulating hormone levels were unchanged.
Conclusions
Biomarker shifts from indole supplementation did not translate into changes in breast density.
Limitations
Short intervention; surrogate endpoints; small sample.
Supplements Studied
Estrogen metabolite ratios shifted modestly but mammographic density and circulating hormone levels were unchanged.
Outcomes Measured
Estrogen metabolite ratios shifted modestly but circulating hormone levels were unchanged.
Study Details
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