The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus
Kawai N, Sakai N, Okuro M, Karakawa S, Tsuneyoshi Y, Kawasaki N
Published in Neuropsychopharmacology
Methodology
Preclinical mechanistic study in rats using systemic glycine, receptor antagonists and suprachiasmatic nucleus lesions
Key Findings
Glycine induced peripheral vasodilation and a drop in core body temperature, promoting non-REM sleep via NMDA receptors in the suprachiasmatic nucleus.
Conclusions
Glycine's sleep effect is plausibly mediated by NMDA-receptor-driven thermoregulatory changes.
Limitations
Animal study; doses and route may not translate to human oral supplementation.
Supplements Studied
Glycine promoted non-rapid eye movement sleep through peripheral vasodilation and a fall in core body temperature mediated by NMDA receptors.
Outcomes Measured
Glycine promoted non-rapid eye movement sleep through peripheral vasodilation and a fall in core body temperature.
Glycine induced peripheral vasodilation and a drop in core body temperature, promoting non-REM sleep via NMDA receptors in the suprachiasmatic nucleus.
Glycine induced peripheral vasodilation and a drop in core body temperature, promoting non-REM sleep via NMDA receptors in the suprachiasmatic nucleus.
Study Details
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