Systematic Review: Efficacy and Safety of Pancreatic Enzyme Supplements for Exocrine Pancreatic Insufficiency
Taylor JR, Gardner TB, Waljee AK, DiMagno EP, Schoenfeld PS
Published in Alimentary Pharmacology and Therapeutics
Methodology
Systematic review of randomised placebo-controlled trials of pancreatic enzyme supplements, undertaken after the FDA questioned the supporting evidence base.
Key Findings
Enzyme supplements improved fat absorption compared with placebo in most trials, but study quality was generally poor, with small samples, varied endpoints and inconsistent reporting of adverse events.
Conclusions
Enzyme supplements appear effective for fat malabsorption, though the evidence base is methodologically weak.
Limitations
Heterogeneous products and outcome definitions; older trials; publication bias possible.
Supplements Studied
Enzyme supplements improved fat absorption compared with placebo in most trials, but study quality was generally poor.
Related Health Concerns
Study Details
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.