Adjuvant use of melatonin for pain management in endometriosis-associated pelvic pain: a randomized double-blinded, placebo-controlled trial
Soderman L, Bottiger Y, Edlund M, Jarnbert-Pettersson H, Marions L
Published in PLOS ONE
Methodology
Randomized, double-blinded, placebo-controlled trial of 20 mg melatonin daily versus placebo for two menstrual cycles in women aged 18-50 with endometriosis and severe dysmenorrhea
Key Findings
Mean pain was 2.9 (SD 1.9) with melatonin versus 3.3 (SD 2.0) with placebo, a difference that was neither statistically nor clinically significant (p=0.45).
Conclusions
Adjuvant melatonin 20 mg did not reduce endometriosis-associated pelvic pain compared with placebo.
Limitations
Small sample with dropouts (34 completers), short two-cycle duration, possibly underpowered.
Supplements Studied
The difference in endometriosis-associated pain between the groups showed to be non-significant statistically as well as clinically
Related Health Concerns
Study Details
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Disclosures
Funding
Regional agreement on medical training and clinical research (ALF), Stockholm
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