S-adenosyl methionine (SAMe) for depression in adults
Galizia I, Oldani L, Macritchie K, Amari E, Dougall D, Jones TN, Lam RW, Massei GJ, Yatham LN, Young AH
Published in Cochrane Database of Systematic Reviews
Key Findings
SAMe was not clearly superior to placebo for depressive symptoms, and evidence versus standard antidepressants was of low quality with no significant difference.
Conclusions
Current evidence is insufficient to support SAMe as an established antidepressant.
Limitations
Small heterogeneous trials, varied routes of administration, low certainty.
Supplements Studied
SAMe was not clearly superior to placebo for depressive symptoms, and evidence versus standard antidepressants was of low quality.
SAMe was not clearly superior to placebo for depressive symptoms, and evidence versus standard antidepressants was of low quality with no significant difference.
Outcomes Measured
SAMe was not clearly superior to placebo for depressive symptoms.
Related Health Concerns
Study Details
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