The effect of vitamin D supplementation on survival in patients with colorectal cancer: systematic review and meta-analysis of randomised controlled trials
Vaughan-Shaw PG, Buijs LF, Blackmur JP, Theodoratou E, Zgaga L
Published in British Journal of Cancer
Methodology
Systematic review and random-effects meta-analysis of seven randomized controlled trials reporting colorectal cancer mortality outcomes
Key Findings
Vitamin D supplementation was associated with a 30% reduction in adverse colorectal cancer outcomes (HR 0.70, 95% CI 0.48-0.93), strongest in trials of established CRC patients
Conclusions
Vitamin D may improve colorectal cancer survival, though trials were heterogeneous
Limitations
Few trials, varied doses and populations, survival not the primary endpoint of most trials
Supplements Studied
meta-analysis found a 30% reduction in adverse CRC outcomes with supplementation (n = 815, HR = 0.70; 95% confidence interval (CI): 0.48-0.93)
Related Health Concerns
Study Details
Access Study
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.