Efficacy of fish oil and its components in the management of psoriasis: a systematic review of 18 randomized controlled trials
Chen X, Hong S, Sun X, Xu W, Li H, Ma T, Zheng Q, Zhao H, Zhou Y, Qiang Y, Li B, Li X
Published in Nutrition Reviews
Methodology
Quantitative systematic review of six databases through March 2019; 18 RCTs with 927 participants evaluating fish oil or omega-3 PUFAs as monotherapy or adjunct in psoriasis.
Key Findings
Fish oil monotherapy had no effect on PASI (P = 0.47), lesion area (P = 0.34) or pruritus (P = 0.62); combined with conventional treatment it reduced PASI (MD -3.92; 95% CI -6.15 to -1.69) and lesion area, and improved cardiometabolic risk markers.
Conclusions
Omega-3 fatty acids are not effective alone but may add benefit alongside conventional psoriasis therapy and improve comorbidity risk factors.
Limitations
Included trials heterogeneous in dose, route (oral vs infusion) and background therapy; several older and at risk of bias.
Supplements Studied
Fish oil or ω-3 PUFAs combined with conventional treatments, however, resulted in a decreased PASI score (mean difference [MD], -3.92; 95%CI, -6.15 to -1.69; P = 0.0006) and lesion area.
Related Health Concerns
Study Details
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Disclosures
Funding
Academic/institutional
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.