Chronic urticaria and vitamin D supplementations: a systematic review
Siddiqui A, Bai A, Kumar H, Mandhwani YR, Bai P, Kumar N, Jatoi S, Ali Z, Parveen A
Published in European Journal of Medical Research
Methodology
PRISMA systematic review of PubMed, Scopus, Web of Science and Google Scholar covering RCTs, case-control and observational studies of serum vitamin D or supplementation in chronic urticaria; bias assessed with Cochrane RoB and Newcastle-Ottawa.
Key Findings
Eleven studies (1,491 participants) showed consistently lower serum 25(OH)D in chronic urticaria patients; supplementation, especially in deficient patients and at high doses (4,000 IU/day or 60,000 IU/week), was associated with lower urticaria activity scores and better quality of life.
Conclusions
Vitamin D supplementation appears to be a useful adjunct in chronic urticaria, particularly for deficient patients, but stronger trials are needed.
Limitations
Marked heterogeneity in design, dose and outcome measures; many included studies observational; no pooled meta-analytic estimate.
Supplements Studied
High-dose regimens (e.g., 4,000 IU/day or 60,000 IU/week) appeared more effective.
Related Health Concerns
Study Details
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Disclosures
Funding
Not reported
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.