Phytochemistry, pharmacology, toxicology and detoxification of Polygonum multiflorum Thunb.
Qian J, Feng C, Wu Z, Yang Y, Gao X
Published in Frontiers in Pharmacology
Methodology
Systematic review of English and Chinese literature (PubMed, Web of Science, CNKI, Wanfang) on the constituents, toxic mechanisms and processing/detoxification strategies of Polygonum multiflorum
Key Findings
The herb is used clinically for hair loss, ageing and insomnia, but its clinical drug safety remains a concern and processing materially changes toxicity.
Conclusions
Traditional uses are not matched by controlled clinical efficacy evidence, while safety signals are well documented.
Limitations
Narrative synthesis; much source evidence is preclinical or Chinese-language case material.
Supplements Studied
While, PM also has some toxicity, its clinical drug safety has been concerned.
Related Health Concerns
Study Details
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Disclosures
Funding
Not reported
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