Disease-modifying therapies for diabetic peripheral neuropathy: A systematic review and meta-analysis of randomized controlled trials

Unknown authors

Published in Journal of Diabetes and its Complications

Key Findings

Nine RCTs, 1153 patients; alpha-lipoic acid plus mecobalamin plus epalrestat outperformed mono- or dual therapy on symptoms and nerve conduction.

Combination therapy including alpha-lipoic acid and mecobalamin may be more effective than monotherapy for diabetic neuropathy.

Compound

Therapeutic outcomes were better in the experimental group than in the control group (odds ratio: 3.74; 95 % confidence interval: 2.57-5.45).

Year:2024

Quality Score:7/10

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