N-acetylcysteine in obsessive-compulsive and related disorders: a systematic review and meta-analysis
Oliver G, Dean O, Camfield D, Blair-West S, Ng C, Berk M, Sarris J
Published in Clinical Psychopharmacology and Neuroscience
Methodology
Systematic review of randomized controlled trials of N-acetylcysteine augmentation in obsessive-compulsive disorder, trichotillomania and related conditions.
Key Findings
NAC augmentation reduced obsessive-compulsive symptom severity in several trials, with the strongest signal in treatment-resistant patients.
Conclusions
NAC shows promise as an adjunct for obsessive thoughts but the trial base is small.
Limitations
Few trials, small samples, variable dosing and duration.
Supplements Studied
NAC augmentation reduced obsessive-compulsive symptom severity in several trials
Outcomes Measured
NAC augmentation reduced obsessive-compulsive symptom severity in several trials, with the strongest signal in treatment-resistant patients
Study Details
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