Homocysteine and Cognitive Function: B Vitamin Supplementation Trial
Smith AD, Smith SM, de Jager CA, Whitbread P, Johnston C, Agacinski G, Oulhaj A, Bradley KM, Jacoby R, Refsum H
Published in PLoS One
Abstract
Randomized controlled trial showing that B vitamin supplementation slows cognitive decline in elderly individuals with mild cognitive impairment.
Methodology
Randomised, double-blind, placebo-controlled trial (VITACOG) with serial MRI to measure whole-brain atrophy rate over 24 months.
Key Findings
In 168 older adults with mild cognitive impairment, high-dose B vitamins (folic acid 0.8 mg, B12 0.5 mg, B6 20 mg) lowered homocysteine by roughly 30% and slowed the rate of brain atrophy by about 30% over two years (0.76%/yr vs 1.08%/yr). Benefit was greatest in those with the highest baseline homocysteine.
Conclusions
Homocysteine-lowering B vitamins slow accelerated brain atrophy in people with mild cognitive impairment and elevated homocysteine, supporting homocysteine as a modifiable risk factor rather than a bystander.
Limitations
Single-centre trial, surrogate imaging endpoint rather than dementia incidence, benefit restricted to participants with raised homocysteine, and results have not been replicated in larger trials.
Supplements Studied
The accelerated rate of brain atrophy in elderly with mild cognitive impairment can be slowed by treatment with homocysteine-lowering B vitamins.
The accelerated rate of brain atrophy in elderly with mild cognitive impairment can be slowed by treatment with homocysteine-lowering B vitamins.
Outcomes Measured
The accelerated rate of brain atrophy in elderly with mild cognitive impairment can be slowed by treatment with homocysteine-lowering B vitamins.
The accelerated rate of brain atrophy in elderly with mild cognitive impairment can be slowed by treatment with homocysteine-lowering B vitamins.
Related Health Concerns
Study Details
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Disclosures
Funding
Charitable and academic funding (Charles Wolfson Charitable Trust, Medical Research Council and others); vitamins supplied by Meda AB
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.