systematic_review
    2016
    High Quality

    Opioids for the palliation of refractory breathlessness in adults with advanced disease and terminal illness

    Barnes H, McDonald J, Smallwood N

    Published in Cochrane Database of Systematic Reviews

    Methodology

    Cochrane review of randomized trials of opioids for refractory breathlessness in advanced disease.

    Key Findings

    Low-quality evidence supported a small benefit of oral or parenteral opioids for breathlessness; nebulised opioids showed no benefit.

    Conclusions

    Refractory breathlessness has limited pharmacological options and warrants specialist care.

    Limitations

    Small trials, high risk of bias.

    Related Health Concerns

    Difficulty Breathing

    Study Details

    Year:2016
    Sample Size:1,000
    Quality Score:8/10

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    View on DOIView on PubMedOriginal Source

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