Omega-3 fatty acids, BDNF and synaptic plasticity in humans: a systematic review of intervention trials
Bhatt DH, Kumar A, Sharma S
Published in Nutrients
Methodology
Systematic review of randomized human trials of omega-3 supplementation reporting BDNF, functional imaging or plasticity-related cognitive outcomes.
Key Findings
Omega-3 supplementation raised circulating BDNF and improved plasticity-linked cognitive measures in several trials, though results were inconsistent in healthy young adults.
Conclusions
Omega-3 fatty acids support neuroplastic signalling mainly where baseline status or cognition is impaired.
Limitations
Heterogeneous doses and outcome markers; BDNF is an indirect plasticity proxy.
Supplements Studied
Omega-3 supplementation raised circulating BDNF and improved plasticity-linked cognitive measures
Outcomes Measured
Omega-3 supplementation raised circulating BDNF and improved plasticity-linked cognitive measures in several trials
Omega-3 supplementation raised circulating BDNF and improved plasticity-linked cognitive measures in several trials, though results were inconsistent in healthy young adults.
Study Details
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