Effect of Hypericum perforatum (St John's wort) in major depressive disorder: a randomized controlled trial
Hypericum Depression Trial Study Group
Published in JAMA
Methodology
Multicentre randomized, double-blind, placebo-controlled trial of Hypericum, sertraline and placebo in 340 adults with moderately severe major depression over 8 weeks.
Key Findings
Neither Hypericum nor sertraline separated significantly from placebo on the primary outcomes.
Conclusions
St John's wort was not effective for moderately severe major depression in this trial.
Limitations
Failed trial design (active comparator also null) limits interpretation; severity higher than typical Hypericum trials.
Supplements Studied
St John's wort was not effective for moderately severe major depression in this trial.
Outcomes Measured
Neither Hypericum nor sertraline separated significantly from placebo on the primary outcomes.
Related Health Concerns
Study Details
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