Overview of pharmacokinetics and liver toxicities of Radix Polygoni Multiflori
Li D, Yang M, Zuo Z
Published in Toxins
Methodology
Critical review of absorption, distribution, metabolism and excretion of Radix Polygoni Multiflori and their relationship to induced liver injury
Key Findings
Emodin exposure from the root is implicated in liver injury through metabolic enzyme alteration, hepatocyte apoptosis and bile-acid disruption.
Conclusions
Preparation and dose govern exposure to the hepatotoxic constituents.
Limitations
Largely preclinical pharmacokinetic data; no human dose-safety threshold.
Supplements Studied
However, its safe and effective application in clinical practice could be hindered by its liver injury potential and lack of investigations on its hepatotoxicity mechanism.
Study Details
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Disclosures
Funding
Not reported
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