Pharmacological and dietary-supplement treatments for autism spectrum disorder: a systematic review and network meta-analysis
Siafis S, Ciray O, Wu H, Schneider-Thoma J, Bighelli I
Published in Molecular Autism
Methodology
Network meta-analysis of 125 RCTs in children/adolescents (n=7450) and 18 RCTs in adults (n=1104) covering 41 drugs and 17 dietary supplements, with core symptoms as co-primary outcomes.
Key Findings
No dietary supplement showed robust, consistent efficacy for core autism symptoms; most supplement evidence was low certainty and driven by small trials.
Conclusions
There is still no treatment with convincing evidence for the core symptoms of ASD; supplement effects are uncertain.
Limitations
Indirect comparisons, sparse networks for individual supplements, heterogeneous rating scales.
Related Health Concerns
Study Details
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Disclosures
Funding
Not specified
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.