systematic_review
    2020

    Grape seed proanthocyanidin extract for chronic venous insufficiency and leg oedema: systematic review of controlled trials

    Kiesewetter H, Koscielny J, Kalus U

    Published in Phytotherapy Research

    Methodology

    Review of controlled trials of oligomeric proanthocyanidins from grape seed in chronic venous insufficiency and lower-limb oedema

    Key Findings

    Several trials reported reductions in leg volume, heaviness and oedema versus placebo, though trials were small and short.

    Conclusions

    Grape seed proanthocyanidins may reduce venous oedema symptoms; evidence quality is moderate at best.

    Limitations

    Small trials, varied extracts, limited long-term data.

    Supplements Studied

    Controlled trials of grape seed proanthocyanidins reported reductions in leg volume, heaviness and oedema in chronic venous insufficiency.

    Related Health Concerns

    Varicose Veins

    Study Details

    Year:2020
    Sample Size:400
    Duration:8 weeks
    Quality Score:6/10

    Access Study

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