Suspected black cohosh hepatotoxicity: no evidence by meta-analysis of randomized controlled clinical trials for isopropanolic black cohosh extract
Naser B, Schnitker J, Minkin MJ, de Arriba SG, Nolte KU, Osmers R
Published in Menopause
Abstract
Meta-analysis of liver safety data from randomized controlled trials of isopropanolic black cohosh extract.
Key Findings
Pooled liver function data from randomized trials of isopropanolic black cohosh extract showed no signal of hepatotoxicity compared with placebo.
Conclusions
Trial-level data do not support the liver-injury signal seen in spontaneous case reports.
Limitations
Manufacturer-affiliated authorship; trials not designed to detect rare hepatic events.
Supplements Studied
Pooled liver function data from randomized trials of isopropanolic black cohosh extract showed no signal of hepatotoxicity compared with placebo.
Study Details
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