observational
    2011

    TLR2 agonist PSK activates human NK cells and enhances the antitumor effect of HER2-targeted monoclonal antibody therapy

    Lu H, Yang Y, Gad E

    Published in Clinical Cancer Research

    Methodology

    Laboratory study of PSK effects on human natural killer cells and murine HER2 tumor models

    Key Findings

    PSK activated NK cells via TLR2 and enhanced the antitumor effect of trastuzumab in models

    Conclusions

    PSK acts as a TLR2 agonist that augments antibody-dependent antitumor immunity

    Limitations

    Preclinical mechanistic study; no human outcomes

    Supplements Studied

    Turkey Tail
    Mushroom

    PSK activated natural killer cells via TLR2 and enhanced antibody-mediated antitumor effects

    Outcomes Measured

    Immune Function

    PSK activated human natural killer cells via TLR2

    Natural Killer Cell Activity

    PSK activated NK cells via TLR2 and enhanced the antitumor effect of trastuzumab in models

    Related Health Concerns

    Breast Cancer

    Study Details

    Year:2011
    Quality Score:4/10

    Access Study

    View on DOIView on PubMedOriginal Source

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