rct
    2004
    High Quality

    The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial

    Atkinson C, Compston JE, Day NE, Dowsett M, Bingham SA

    Published in American Journal of Clinical Nutrition

    Key Findings

    Red clover isoflavones attenuated loss of lumbar spine bone mineral content over one year, with no significant effect on hip bone density.

    Conclusions

    Possible modest skeletal benefit at the spine, not confirmed at other sites.

    Limitations

    Single trial; surrogate bone endpoints; no fracture data.

    Supplements Studied

    Red clover isoflavones attenuated loss of lumbar spine bone mineral content over one year.

    Outcomes Measured

    Bone Mineral Density
    Primary

    Isoflavone treatment slowed lumbar spine bone mineral content loss over one year.

    Related Health Concerns

    Osteoporosis

    Study Details

    Year:2004
    Sample Size:205
    Duration:52 weeks
    Quality Score:7/10

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