rct
2025
High Quality
Long-term effects and effect heterogeneity of lifestyle and metformin interventions on type 2 diabetes incidence over 21 years in the Diabetes Prevention Program Outcomes Study
Unknown authors
Published in Lancet Diabetes and Endocrinology
Key Findings
Over 21 years of follow-up, both intensive lifestyle intervention and metformin continued to reduce cumulative type 2 diabetes incidence versus placebo, with heterogeneity by baseline risk.
Conclusions
Lifestyle and metformin remain the benchmark interventions for lowering long-term diabetes incidence.
Outcomes Measured
Diabetes Incidence
Primary
Long-term effects and effect heterogeneity of lifestyle and metformin interventions on type 2 diabetes incidence over 21 years in the Diabetes Prevention Program Outcomes Study.
Related Health Concerns
Study Details
Year:2025
Quality Score:10/10
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