Evidence of Astragalus injection combined platinum-based chemotherapy in advanced nonsmall cell lung cancer patients: A systematic review and meta-analysis
Cao A, He H, Wang Q, Li L, Zhou X
Published in Medicine
Methodology
Systematic review and meta-analysis of 19 randomised controlled trials (1635 patients) of Astragalus injection plus platinum-based chemotherapy versus chemotherapy alone in advanced non-small cell lung cancer, graded with GRADE.
Key Findings
Astragalus injection plus chemotherapy improved objective response rate (RR = 1.19, 95% CI 1.06-1.33), Karnofsky performance status (RR = 2.28) and one-year survival (RR = 1.40, 95% CI 1.16-1.70) versus chemotherapy alone.
Conclusions
Astragalus injection may enhance response and immune parameters alongside platinum chemotherapy, but the evidence base is low quality.
Limitations
Injectable preparation, not an oral supplement; all trials conducted in China; low GRADE certainty and unclear blinding.
Supplements Studied
AGI combined chemotherapy could significantly improve the objective response rate (relative risk [RR] = 1.19, 95% confidence interval [CI] [1.06, 1.33], P = .002).
Related Health Concerns
Study Details
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Disclosures
Funding
Not reported
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