Vanadium compounds with antidiabetic potential
Amaral LMPF, Silva AMN
Published in International Journal of Molecular Sciences
Methodology
Narrative and mechanistic review of vanadium coordination compounds, insulin-mimetic pathways and the human clinical trial record.
Key Findings
Insulin-mimetic activity is well documented in animal models but human trials remain small, short and confounded by gastrointestinal toxicity and accumulation concerns.
Conclusions
Vanadium remains a preclinical concept for diabetes; no clinically validated oral formulation exists.
Limitations
Narrative review without formal risk-of-bias assessment.
Supplements Studied
Insulin-mimetic activity is well documented in animal models, but human trials remain small and confounded by toxicity concerns.
Study Details
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