Does the use of proton pump inhibitors increase the risk of hypomagnesemia: An updated systematic review and meta-analysis
Liao S, et al.
Published in Medicine (Baltimore)
Methodology
Updated systematic review and random-effects meta-analysis of observational cohort and cross-sectional studies reporting serum magnesium or hypomagnesaemia in PPI users versus non-users.
Key Findings
Meta-analysis of observational studies (129,347 participants) found proton pump inhibitor use was associated with a significantly increased risk of hypomagnesaemia (pooled OR approximately 1.44), with risk higher in patients concurrently taking diuretics and in longer-duration users.
Conclusions
The association between the exposure to PPI and the incidence of hypomagnesemia remained unclear.
Limitations
Entirely observational data with confounding by indication and comorbidity; heterogeneous hypomagnesaemia thresholds across studies; magnesium measured as serum level, a poor proxy for total body stores; no randomised evidence available.
Related Health Concerns
Study Details
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Disclosures
Funding
No external funding declared
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