Is the addition of sublingual melatonin to omeprazole superior to omeprazole alone in the management of gastroesophageal reflux disease symptoms: a clinical trial
Malekpour H, Noori A, Abdi S, Abbasinazari M, Mahboubi A
Published in The Turkish Journal of Gastroenterology
Methodology
Randomized double-blind clinical trial in 78 GERD patients allocated to omeprazole 20 mg/day plus sublingual melatonin 3 mg/day or omeprazole plus placebo for four weeks, with heartburn, epigastric pain and Frequency Scale for the Symptoms of GERD score as outcomes
Key Findings
Adding sublingual melatonin to omeprazole improved reflux symptom scores compared with omeprazole plus placebo over four weeks.
Conclusions
Melatonin is best supported as an adjunct to acid suppression, not a replacement.
Limitations
Single centre; 78 patients; four weeks; add-on design only.
Supplements Studied
The present study aimed to investigate whether the addition of sublingual melatonin to omeprazole was effective in the treatment of gastro gastroesophageal reflux disease symptoms.
Related Health Concerns
Study Details
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Disclosures
Funding
Not reported
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