Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial
Cheung AM, Tile L, Lee Y, Tomlinson G, Hawker G, Scher J
Published in PLoS Medicine
Methodology
Two- to four-year randomised placebo-controlled trial of phylloquinone 5 mg daily in 440 postmenopausal women with osteopenia.
Key Findings
No effect on bone mineral density at any site; an exploratory analysis suggested fewer clinical fractures and cancers, considered hypothesis-generating.
Conclusions
Daily high-dose vitamin K1 did not protect against bone mineral density loss in postmenopausal women with osteopenia.
Limitations
Fracture findings were secondary and underpowered; open-label extension.
Supplements Studied
Daily 5 mg vitamin K1 did not protect against bone mineral density loss in postmenopausal women with osteopenia.
Outcomes Measured
No effect on bone mineral density at any site; an exploratory analysis suggested fewer clinical fractures and cancers, considered hypothesis-generating.
Related Health Concerns
Study Details
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.