Long-term high copper intake: effects on indexes of copper status, antioxidant status, and immune function in young men
Turnlund JR, Jacob RA, Keen CL, Strain JJ, Kelley DS, Domek JM, Keyes WR, Ensunsa JL, Lykkesfeldt J, Coulter J
Published in American Journal of Clinical Nutrition
Methodology
Controlled metabolic feeding study in young men consuming 7.8 mg/day copper for 147 days with repeated copper status, antioxidant and immune measures.
Key Findings
Long-term high copper intake did not impair most indexes of copper status but produced changes in antioxidant status and a decline in some immune indices.
Conclusions
Sustained high copper intake is tolerated but may adversely affect immune and antioxidant indices.
Limitations
Small all-male sample, controlled feeding setting not generalizable, surrogate biomarkers only.
Supplements Studied
Long-term high copper intake did not impair most indexes of copper status but produced changes in antioxidant status and a decline in some immune indices.
Outcomes Measured
Long-term high copper intake produced changes in antioxidant status and a decline in some immune indices.
Study Details
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