Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Day E, Bentham PW, Callaghan R
Published in Cochrane Database of Systematic Reviews
Methodology
Cochrane review of RCTs of thiamine for Wernicke-Korsakoff syndrome in alcohol misuse.
Key Findings
Evidence is insufficient to define optimal dose or route, but thiamine remains standard care given the severity of untreated confusion and ataxia.
Conclusions
Thiamine repletion is essential where deficiency-related confusion is suspected, despite thin trial evidence.
Limitations
Only two small trials met inclusion criteria.
Supplements Studied
Thiamine remains standard care given the severity of untreated confusion and ataxia.
Outcomes Measured
Thiamine remains standard care given the severity of untreated confusion and ataxia.
Related Health Concerns
Study Details
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