Posttraumatic stress disorder is associated with reduced vitamin D levels and functional polymorphisms of the vitamin D binding-protein in a population-based sample
Terock J
Published in Progress in Neuro-Psychopharmacology and Biological Psychiatry
Methodology
Population-based cohort analysis with structured psychiatric interview for PTSD, serum 25(OH)D measurement and genotyping of vitamin D binding protein polymorphisms; multivariable regression with interaction terms.
Key Findings
In a population-based sample of 1,653 adults (Study of Health in Pomerania), participants with PTSD had significantly lower serum 25(OH)D than those without, and functional polymorphisms of the vitamin D binding protein (GC gene) modified the association between traumatic experience and PTSD symptoms, pointing to gene-environment interaction rather than simple deficiency.
Conclusions
Vitamin D deficiency was associated with PTSD in a population-based sample; causality unestablished.
Limitations
Cross-sectional cohort analysis - reverse causation is likely, since PTSD reduces outdoor activity and sun exposure; single vitamin D measurement with seasonal variation; genetic subgroup analyses exploratory and multiple-comparison prone; no interventional data.
Supplements Studied
25(OH)D levels were inversely and vitamin D deficiency positively associated with PTSD.
Related Health Concerns
Study Details
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Disclosures
Funding
German Federal Ministry of Education and Research and the state of Mecklenburg-West Pomerania
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