systematic_review
    2024

    Comprehensive review of the traditional uses and the potential benefits of Epimedium folium

    Lin L, Shi Z, Gao Y, Yang T, Wang L

    Published in Frontiers in Pharmacology

    Methodology

    Comprehensive review of phytochemistry, pharmacology, toxicity and clinical use of Epimedium folium

    Key Findings

    Icariin and related flavonoids show osteogenic, vasodilatory and immunomodulatory activity in preclinical models, but rigorous human trials of single-herb Epimedium are largely absent.

    Conclusions

    Epimedium evidence remains dominated by preclinical pharmacology rather than controlled human trials.

    Limitations

    Narrative synthesis; heterogeneous preparations; publication bias in Chinese literature.

    Supplements Studied

    Rigorous human trials of single-herb Epimedium are largely absent.

    Study Details

    Year:2024
    00
    Quality Score:6/10

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