rct
    2015
    High Quality

    Effect of sulforaphane in men with biochemical recurrence after radical prostatectomy

    Cipolla BG, Mandron E, Lefort JM, Coadou Y, Della Negra E, Corbel L, Le Scodan R, Azzouzi AR, Mottet N

    Published in EBioMedicine

    Methodology

    Randomized, double-blind, placebo-controlled trial of 60 mg/day sulforaphane for 6 months in 78 men with rising PSA after prostatectomy.

    Key Findings

    PSA doubling time was 86% longer with sulforaphane, though the primary endpoint of PSA change was not significantly different.

    Conclusions

    Sulforaphane slowed PSA rise but did not meet its primary endpoint.

    Limitations

    Surrogate biochemical endpoint; modest sample; no survival data.

    Supplements Studied

    Sulforaphane
    Compound

    Sulforaphane slowed PSA rise but did not meet its primary endpoint.

    Study Details

    Year:2015
    Sample Size:78
    Duration:26 weeks
    Quality Score:7/10

    Access Study

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