Indole-3-carbinol as a chemopreventive agent: mechanisms, clinical evidence and safety considerations
Ahmad A, Sakr WA, Rahman KM
Published in Current Drug Targets
Methodology
Review of preclinical mechanisms and human evidence for indole-3-carbinol and its condensation product DIM in cancer chemoprevention
Key Findings
Indole-3-carbinol modulates estrogen metabolism, cell-cycle arrest and NF-kB signalling in preclinical models, but human chemoprevention evidence remains limited to small biomarker studies.
Conclusions
The chemopreventive case for indole-3-carbinol is mechanistic rather than clinically proven.
Limitations
Narrative review; dominated by cell and animal data.
Supplements Studied
Human chemoprevention evidence remains limited to small biomarker studies.
Outcomes Measured
Indole-3-carbinol modulates estrogen metabolism in preclinical models, with limited human evidence.
Study Details
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