rct
    2014

    Anti-anhedonic effect of ketamine and its neural correlates in treatment-resistant bipolar depression

    Lally N, Nugent AC, Luckenbaugh DA, Ameli R, Roiser JP, Zarate CA

    Published in Translational Psychiatry

    Key Findings

    A single ketamine infusion reduced anhedonia within 40 minutes, independent of overall depression improvement, with effects lasting up to 14 days.

    Conclusions

    Anhedonia and emotional numbing can respond rapidly to glutamatergic treatment.

    Limitations

    Small crossover sample, specialist setting.

    Outcomes Measured

    Depression Symptom Reduction

    Ketamine rapidly reduced anhedonia independent of overall depressive symptom change.

    Related Health Concerns

    Emotional Numbness
    Depression

    Study Details

    Year:2014
    Sample Size:36
    Duration:2 weeks
    Quality Score:6/10

    Access Study

    View on DOIView on PubMedOriginal Source

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