Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women: a double-blind randomised clinical trial
Knapen MH, Braam LA, Drummen NE, Bekers O, Hoeks AP, Vermeer C
Published in Thrombosis and Haemostasis
Methodology
Three-year double-blind randomised placebo-controlled trial of MK-7 180 mcg/day with carotid ultrasound and pulse wave velocity endpoints in 244 postmenopausal women.
Key Findings
Carotid artery stiffness and pulse wave velocity decreased significantly with MK-7, with the largest benefit in women with high baseline stiffness.
Conclusions
Long-term MK-7 supplementation improves arterial stiffness in healthy postmenopausal women.
Limitations
Surrogate vascular endpoints only; single population and dose.
Supplements Studied
Carotid artery stiffness and pulse wave velocity decreased significantly after three years of MK-7.
Outcomes Measured
Pulse wave velocity and carotid stiffness improved significantly with menaquinone-7.
Related Health Concerns
Study Details
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