Single-nucleotide polymorphisms of HLA and Polygonum multiflorum-induced liver injury in the Han Chinese population
Yang WN, Pang LL, Zhou JY, Qiu YW, Miao L
Published in World Journal of Gastroenterology
Methodology
Case-control study of 382 participants from four hospitals (73 PM-DILI patients, 118 other-DILI patients, 191 healthy controls) with whole-exome sequencing and candidate SNP genotyping
Key Findings
Specific host genetic variants, alongside HLA-B*35:01, mark susceptibility to Polygonum multiflorum liver injury.
Conclusions
Risk of liver injury is host-dependent rather than uniform across users.
Limitations
Single ethnic population; retrospective case ascertainment.
Supplements Studied
We conducted a systematic study enrolling 382 participants from four independent hospitals, including 73 PM-DILI patients, 118 patients with other drug-induced liver injury (other-DILI) and 191 healthy controls.
Study Details
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Disclosures
Funding
Not reported
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